Considerations for co-enrolment in randomised controlled effectiveness trials in critical care: the SPICE-8 co-enrolment guidelines.

Making Co-Enrolment Feasible for Randomised Controlled Trials in Paediatric Intensive Care

AIMS Enrolling children into several trials could increase recruitment and lead to quicker delivery of optimal care in paediatric intensive care units (PICU). We evaluated decisions taken by clinicians and parents in PICU on co-enrolment for two large pragmatic trials: the CATCH trial (CATheters in CHildren) comparing impregnated with standard central venous catheters (CVCs) for reducing bloods...

Co-enrolment for the TAME and TTM-2 trials: the cerebral option.

A systematic review of techniques and interventions for improving adherence to inclusion and exclusion criteria during enrolment into randomised controlled trials

BACKGROUND Enrolment of patients into a randomised controlled trial (RCT) in violation of key inclusion or exclusion criteria, may lead to excess avoidable harm. The purpose of this paper was to systematically identify and review techniques and interventions proven to prevent or avoid inappropriate enrolment of patients into RCTs. METHODS EMBASE, MEDLINE, Cochrane Database of Systematic Revie...

Outreach strategies for expanding health insurance coverage in children.

BACKGROUND Health insurance has the potential to improve access to health care and protect people from healthcare costs when they are ill. However, coverage is often low, particularly in people most in need of protection. OBJECTIVES To assess the effectiveness of outreach strategies for expanding insurance coverage of children who are eligible for health insurance schemes. SEARCH STRATEGY W...

Methodological considerations for neonatal trials involving multiples: lessons from the bracelet study (bereavement and randomised controlled trials)

Neonatal trials which include preterm babies often recruit multiples (twins or higher order births). For such trials, methodological decisions must be made regarding recruitment and randomisation of multiples. Enrolment can take place in complicated and challenging situations which are compounded if one or more babies die. In the BRACELET Study (Bereavement and Randomised Controlled Trials) (ht...